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rebuilding-glomerular-filtration-barrier | ATLAS-D2K Center
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Rebuilding the Glomerular Filtration Barrier by Regenerating Adult Podocytes

Key Personnel

Stuart J. Shankland (PI)
University of Washington

Ying Zheng (PI)
University of Washington

  • Ryan Nagao
    University of Washington
  • Jeffrey Pippin
    University of Washington

Project Description

Our project aims to rebuild kidney glomeruli by regenerating podocytes, terminally differentiated cells in the kidney glomerular filtering units that limit the passage of proteins from the blood into the urine, from two candidate resident stem/progenitor cells, cells of renin lineage (CoRL) and parietal epithelial cells (PECs). We will use an in vitro flow-directed microphysiological system (3D MPS) to determine to what degree CoRL and PECs are truly podocyte progenitors to rebuild a kidney, how their micro-environment regulates their fate, and what critical pathways are required for their reprogramming and fate to replace depleted adult podocytes.