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generating-organoids | ATLAS-D2K Center
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Generating Kidney Organoids and Mature Renal Cell Types Via Directed iPSC Differentiation

Key Personnel

Melissa H. Little (PI)
Murdoch Childrens Research Institute

  • Andrew Elefanty
    Murdoch Childrens Research Institute
  • Pei Er
    Murdoch Childrens Research Institute
  • Sara Howden
    Murdoch Childrens Research Institute
  • Alicia Oshlack
    Murdoch Childrens Research Institute
  • Belinda Phipson
    Murdoch Childrens Research Institute
  • Ed Stanley
    Murdoch Childrens Research Institute
  • Jess Vanslambrouck
    Murdoch Childrens Research Institute

Project Description

We have previously shown that human kidney tissue can be generated from human pluripotent stem cells. Our project focuses on characterizing and optimizing this approach to improve tubular maturation and cellular function and generating reporter lines for the isolation of specific cell types. In the long term, human kidney tissue generated in this way may be used for drug screening, tissue regeneration or cell therapy.